Inhibitors targeting DNA Damage Response (DDR)
DNA Damage Response Inhibition is an anti-cancer platform which could revolutionize the treatment of cancer. It works by exploiting DNA
Candidates
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PARP Iinhibitors
IMPACT has discovered two series of novel PARP inhibitors with more than 60 novel compounds that are many folds more potent than AZD2281
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Hedgehog Pathway Inhibitors
IMPACT has discovered three series of novel Hedgehog pathway inhibitors and has identified more than 10 compounds that are 10-100 folds more potent than the approved Hedgehog inhibitor GDC-044
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Microtubule Inhibitor
IMPACT has discovered two series of novel small molecular microtubule inhibitors, and selected IMP3138 as a clinical candidate for further development.
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